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Apurun

C12-200 (Ionizable)

C12-200 (Ionizable)

Regular price $525.00 USD
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cKK-E12 (Ionizable Lipid)

Ionizable lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 has been used to deliver siRNA in mice, rats, and primates (ED50 = 0.002, 0.01, & 0.3 mg/kg respectively). It shows low toxicity and is selective for liver parenchymal cells over liver, heart, lung, and kidney endothelial cells. This product is for research use only and not for human use. Additional information can be found here.

Chemical Specifications

  • CAS Number: 1432494-65-9
  • Molecular Formula: C60H120N4O6
  • Molecular Weight: Approximately 993.64 g/mol
  • Purity: 0.95

Physical and Chemical Properties

  • Solubility: Chloroform, methanol, ethanol
  • Storage: Store dry at 4°C or below. Stock solutions should be stored at -20°C.
  • Shipping Temperature: Gel Ice

Background

Cationic lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 has been used to deliver siRNA in mice, rats, and primates (ED50 = 0.002, 0.01, & 0.3 mg/kg respectively). It shows low toxicity and is selective for liver parenchymal cells over liver, heart, lung, and kidney endothelial cells. This product is for research use only and not for human use.

References

  1. Dong et al. (2014) Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. PNAS Mar 18;111(11):3955-60
  2. M.A. Oberli, A.M.Reichmuth, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett, 17, 1326 (2017).
  3. Miao, L., Lin, J., Huang, Y. et al. Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver. Nat Commun 11, 2424 (2020).
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