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Apurun

Lipid-5 (Ionizable)

Lipid-5 (Ionizable)

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Lipid-5 (Ionizable)

Ionizable lipids, when combined with other lipids, make up the lipid nanoparticles (LNPs) used to deliver RNA-based therapeutics. LNPs incorporating Lipid 5 (from Sabnis et al.) have shown potent delivery of mRNA in primates, although they are rapidly cleared from the body, resulting in low toxicity. Lipid 5 is particularly effective for intravenous delivery to the liver, whereas the closely related SM-102 is optimized for intramuscular administration. This product is intended for research purposes only and is not for human use.

Chemical Specifications

  • CAS Number: 2089251-33-0
  • Molecular Formula: C44H87NO5
  • Molecular Weight: 710.18 g/mol

Physical and Chemical Properties

  • Solubility: Chloroform, methanol, ethanol
  • Alternate Name: Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate
  • Storage and Handling: Store dry at -20°C or below. Stock solutions should be stored at -20°C.
        
        
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