Lipid nanoparticles (LNPs) have emerged as transformative agents in chimeric antigen receptor (CAR) T cell therapy, offering significant advantages over traditional methods. They address key challenges such as immunogenicity, reduced toxicity, and improved safety. Promising preclinical results indicate a shift towards safer and more effective CAR T cell treatments. Ongoing research is focused on validating these findings in clinical trials, marking the beginning of a new era in CAR therapy. This exploration highlights the preference for LNPs due to their versatility and effective delivery of nucleic acids. Additionally, we discuss the key clinical challenges, heralding a new era in CAR T cell therapy driven by the utility of LNPs.
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