DLin-MC3-DMA is a highly effective ionizable lipid used in the formulation of lipid nanoparticles (LNPs) for delivering nucleic acids, such as mRNA and siRNA. When dissolved in ethanol, DLin-MC3-DMA serves as a key component in the formation of LNPs, providing the necessary cationic charge that facilitates the encapsulation of nucleic acids. This lipid has gained prominence in the development of LNP-based vaccines and gene therapies due to its optimal balance between stability and efficacy.

DLin-MC3-DMA in ethanol offers enhanced solubility and integration into lipid nanoparticle formulations. This ionizable lipid transitions between neutral and cationic states depending on pH, which is crucial for effective nucleic acid encapsulation and release. The ethanol solvent helps maintain the homogeneity and stability of the lipid during formulation processes, ensuring consistent particle size and delivery efficiency.

Store DLin-MC3-DMA in ethanol at 4°C in tightly sealed containers to prevent solvent evaporation and degradation. Avoid prolonged exposure to light and ensure that the product is handled under inert conditions to prevent oxidation and maintain the lipid's functional integrity.

DLin-MC3-DMA in ethanol is shipped at 4°C using insulated packaging to maintain the appropriate temperature during transit. This ensures that the lipid remains stable and ready for use upon arrival.

ALC-0315 is an ionizable lipid widely used in the formulation of LNPs for the delivery of mRNA. Its role in drug delivery systems is to facilitate the encapsulation and intracellular release of nucleic acids, providing the necessary cationic environment for efficient endosomal escape. In ethanol, ALC-0315 is prepared to ensure uniform distribution and solubility within LNP formulations, contributing to the stability and efficacy of the final product.

ALC-0315 in ethanol is highly soluble, making it ideal for incorporation into LNP formulations. Its ionizable nature allows it to interact with nucleic acids effectively, transitioning between charged states in response to environmental pH. This property is crucial for the successful delivery of therapeutic agents within cellular environments, enhancing the overall efficacy of the drug delivery system.

ALC-0315 in ethanol should be stored at 4°C to maintain its stability and prevent degradation. It is important to handle the lipid in a controlled environment, minimizing exposure to light and oxygen to preserve its functionality. Once thawed, the product should be used immediately to avoid degradation.

ALC-0315 in ethanol is shipped at 4°C with appropriate temperature control measures to maintain stability during shipping, ensuring the lipid is in optimal condition for use in LNP formulation immediately upon receipt.

C12-200 is an ionizable lipid known for its ability to form stable and effective LNPs for gene delivery applications. In ethanol, C12-200 is utilized to enhance the solubility and integration of the lipid within nanoparticle formulations. Its unique structure allows for efficient nucleic acid encapsulation, which is essential for the delivery of therapeutic mRNA and siRNA in various treatments.

C12-200’s structure facilitates the formation of uniform and stable LNPs, which are crucial for consistent drug delivery. The ethanol solution not only maintains the lipid’s solubility but also supports its dispersion within the formulation, ensuring effective encapsulation of nucleic acids. The ionizable nature of C12-200 is particularly beneficial for achieving high transfection efficiency in targeted cells.

Store C12-200 in ethanol at 4°C, protected from light and moisture. Handling should involve minimizing exposure to air to prevent oxidation. The ethanol solution should be kept tightly sealed when not in use, and thawed portions should be used promptly to ensure maximum efficacy.

C12-200 in ethanol is shipped at 4°C in temperature-controlled packaging to ensure stability during transit, allowing for immediate use in LNP production upon arrival.

SM-102 is an ionizable lipid prominently used in the formulation of LNPs, particularly in mRNA vaccine delivery systems. Its ionizable nature allows it to transition between neutral and cationic forms depending on the pH, which is crucial for the effective encapsulation and release of nucleic acids within cells. When dissolved in ethanol, SM-102 is prepared for easy integration into nanoparticle formulations, ensuring consistent particle size and delivery efficiency.

SM-102 in ethanol enhances the solubility and uniform distribution of the lipid within LNP formulations. The ionizable properties of SM-102 make it highly effective in delivering nucleic acids, as it facilitates the endosomal escape of the payload, increasing the therapeutic efficacy of the formulation. Ethanol helps maintain the lipid's stability during storage and handling.

Store SM-102 in ethanol at 4°C to preserve its integrity. The product should be handled under inert conditions, such as a nitrogen atmosphere, to avoid oxidation. Once thawed, SM-102 should be used promptly to ensure its effectiveness in LNP formulations.

SM-102 in ethanol is shipped at 4°C using insulated and temperature-controlled packaging to maintain its stability during transportation, ensuring the lipid remains effective for immediate use in nanoparticle formulations.

Lipid-5 is an ionizable lipid that plays a critical role in the formulation of LNPs for the delivery of therapeutic nucleic acids. Its ability to efficiently encapsulate and release genetic material within target cells makes it an essential component in mRNA and siRNA delivery systems. In ethanol, Lipid-5 is dissolved to enhance its solubility and ensure that it can be uniformly distributed during the nanoparticle formation process.

The ethanol solution of Lipid-5 allows for easy handling and integration into LNP formulations. This lipid’s ionizable characteristics make it highly effective in forming stable nanoparticles that can deliver therapeutic agents efficiently. The ethanol solvent supports the stability of Lipid-5, preventing it from degrading over time and ensuring consistent performance in drug delivery applications.

Lipid-5 in ethanol should be stored at 4°C in a well-sealed container to prevent solvent evaporation and protect the lipid from light and air. Handling should be conducted under inert conditions to maintain the lipid's stability and functionality. Once thawed, the lipid should be used immediately to ensure its efficacy in LNP formulations.

Lipid-5 in ethanol is shipped at 4°C with temperature-controlled packaging to ensure stability during transit, preserving the lipid’s properties for immediate use in LNP production upon arrival.

DODMA is an ionizable cationic lipid used in the formulation of LNPs for the delivery of nucleic acids. Its cationic properties at acidic pH levels make it highly effective in binding and encapsulating genetic material, facilitating its delivery into cells. In ethanol, DODMA is prepared to ensure optimal solubility and distribution within the lipid mixture, which is crucial for the consistency and effectiveness of the final nanoparticle product.

DODMA’s ionizable properties allow it to transition between different charge states, enhancing its ability to encapsulate nucleic acids effectively. The ethanol solution ensures that DODMA remains soluble and evenly distributed in LNP formulations, contributing to the uniformity and stability of the nanoparticles. This characteristic is particularly important for maintaining high transfection efficiency in gene delivery applications.

Store DODMA in ethanol at 4°C in a tightly sealed container to prevent evaporation and oxidation. Handling should be done under inert conditions, such as in a nitrogen-purged environment, to avoid exposure to moisture and air, which could degrade the lipid. Thawed DODMA should be used immediately to maintain its functional integrity.

DODMA in ethanol is shipped at 4°C using insulated packaging to maintain the appropriate temperature during transit, ensuring the lipid remains stable and ready for use in LNP formulation upon arrival.

9A1P9 is an ionizable lipid that contributes to the formation of LNPs used in gene delivery systems. Its ability to switch between charged and neutral states depending on the pH makes it particularly effective in protecting and delivering nucleic acids to target cells. In ethanol, 9A1P9 is prepared to ensure that it is evenly distributed within the lipid mixture, promoting uniform particle formation during the manufacturing process.

The use of 9A1P9 in ethanol ensures that the lipid is fully dissolved and ready for incorporation into LNPs. Its ionizable nature is key to achieving efficient encapsulation and release of therapeutic agents. The ethanol solvent stabilizes 9A1P9, making it easier to handle and integrate into the formulation process, ensuring consistent nanoparticle size and performance.

9A1P9 in ethanol should be stored at 4°C to maintain its stability. It is important to protect the lipid from exposure to air and light, which could lead to oxidation and degradation. The lipid should be used promptly after thawing to ensure that it retains its functional properties in LNP formulations.

9A1P9 in ethanol is shipped at 4°C using insulated packaging to maintain the appropriate temperature during transit. This ensures the lipid arrives in optimal condition, ready for immediate use in nanoparticle production.

DOTAP is a well-known cationic lipid used in the formulation of liposomes and LNPs for the delivery of DNA, RNA, and other therapeutic agents. Its positive charge allows it to interact effectively with negatively charged nucleic acids, facilitating their encapsulation and delivery to target cells. Dissolved in ethanol, DOTAP is prepared for easy integration into lipid formulations, ensuring consistent and reproducible nanoparticle production.

DOTAP in ethanol provides a highly soluble form of the lipid, ready for incorporation into LNPs and liposomes. The cationic nature of DOTAP makes it ideal for binding to nucleic acids, forming stable complexes that enhance the delivery and efficacy of therapeutic agents. The ethanol solution ensures that DOTAP is evenly distributed within the formulation, contributing to the uniformity of the final product.

Store DOTAP in ethanol at 4°C in a sealed container to prevent solvent evaporation and lipid degradation. Handle under inert conditions to avoid oxidation and maintain the lipid’s effectiveness. Use the lipid immediately after thawing to ensure its functionality in nanoparticle and liposome formulations.

DOTAP in ethanol is shipped at 4°C using temperature-controlled packaging to ensure stability during transit, preserving the lipid’s properties for immediate use in the production of drug delivery systems.