Full Panel Analytical Panel & Characterization Services for Novel Nanomedicines

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Apurun offers a comprehensive suite of analytical methods for liposomal and lipid nanoparticle quality control, meticulously aligned with FDA guidelines and GMP quality standards. These methods encompass both physical and chemical assays to ensure the robustness and efficacy of drug delivery systems. Some of the key analytical methods include:

  • Particle Size Analysis: Utilizing techniques such as dynamic light scattering (DLS) or nanoparticle tracking analysis (NTA) to measure the size distribution and average particle size of liposomal and lipid nanoparticles.
  • Zeta Potential Measurement: Assessing the surface charge of nanoparticles, which influences stability, using techniques like electrophoretic light scattering.
  • Encapsulation Efficiency Determination: Quantifying the amount of drug encapsulated within the nanoparticles through methods such as ultracentrifugation or chromatography.
  • Drug Release Studies: Evaluating the release profile of drugs from nanoparticles under various conditions, providing insights into drug delivery kinetics.
  • Stability Studies: Conducting accelerated and real-time stability tests to assess the physical and chemical stability of nanoparticles over time.
  • Morphological Characterization: Employing techniques like transmission electron microscopy (TEM) or scanning electron microscopy (SEM) to visualize the morphology and structure of nanoparticles.
  • Ribogreen Assay: Quantifying nucleic acid content within nanoparticles using fluorescence-based assays such as Ribogreen.
  • HPLC Purity Analysis: Determining the purity of drug compounds within nanoparticles through high-performance liquid chromatography (HPLC).
  • GC-FID Residual Solvent Analysis: Detecting and quantifying residual solvents in nanoparticle formulations using gas chromatography with flame ionization detection (GC-FID).
  • Plate Reader Assays: Conducting various plate reader assays to assess cellular uptake, cytotoxicity, or other functional aspects of nanoparticle formulations.
  • ELISA: Employing enzyme-linked immunosorbent assays (ELISA) to quantify specific proteins or biomarkers encapsulated within nanoparticles.
  • UV-Vis Spectrometry: Measuring absorbance or transmission of light by nanoparticles using UV-Vis spectrophotometry, providing insights into concentration and stability.

From Preclinical to Patients, Our Experts Are Prepared to Support You

For individual sample orders, Apurun provides access to these analytical methods to ensure the quality and consistency of liposomal and lipid nanoparticle formulations. Moreover, through partnerships, Apurun collaborates globally to design, characterize, and optimize drug delivery systems, leveraging its expertise and cutting-edge analytical capabilities to drive innovation and advance therapeutic development.

Our Custom Drug Delivery Offerings Include:

  • Lipid-Based DDS: Leveraging our expertise in lipid nanoparticle technology, we design lipid-based delivery systems that enhance the solubility, stability, and bioavailability of your therapeutic compounds.
  • Polymeric DDS: With advanced polymer science capabilities, we develop polymeric delivery systems that offer controlled release, targeting, and biocompatibility, tailored to your specific drug and application requirements.
  • Hybrid DDS: Our hybrid delivery systems combine the advantages of lipids and polymers to create synergistic effects, providing enhanced therapeutic efficacy and versatility.

Tailored Solutions for Various Disease and Tissue Indications:

  • Oncology
  • Infectious diseases
  • Neurological disorders
  • Autoimmune diseases
  • Cardiovascular conditions
  • Dermatological conditions
  • Ophthalmic treatments
  • And many more

Why Choose Apurun for Your Custom Drug Delivery Needs?

  • Expertise and Experience: Our team of scientists and engineers brings years of experience in drug delivery research and development, ensuring high-quality, innovative solutions.
  • Customization: We work closely with you to understand your specific requirements and develop tailored solutions that meet your exact specifications.
  • Cutting-Edge Technology: Leveraging the latest advancements in nanoparticle engineering and formulation science, we deliver state-of-the-art drug delivery systems.
  • Regulatory Compliance: Our commitment to quality and regulatory compliance ensures that our custom drug delivery solutions meet the highest industry standards.