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Apurun

DLin-DMA (Ionizable)

DLin-DMA (Ionizable)

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DLin-DMA

DLin-DMA: DLin-DMA is an ionizable lipid used in combination with other lipids to formulate lipid nanoparticles (LNPs) for the delivery of nucleic acids such as siRNA and mRNA. Studies have demonstrated the efficacy of DLin-DMA-based LNPs in delivering nucleic acids to target cells both in vitro and in vivo.

Chemical Specifications

  • Formal Name: N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-1-propanamine
  • CAS Number: 871258-12-7
  • Synonyms: 1,2-Dilinoleyloxy-N,N-dimethyl-3-aminopropane
  • Molecular Formula: C41H77NO2
  • Purity: ≥95%
  • Formulation: A solution in ethanol (Request formulation change)
  • Solubility:
    • DMF: 2 mg/ml
    • DMSO: insol
    • Ethanol: 10 mg/ml
    • PBS (pH 7.2): insol
  • SMILES: CCCCC/C=C\C/C=C\CCCCCCCCOCC(CN(C)C)OCCCCCCCC/C=C\C/C=C\CCCCC
  • InChi Code: InChI=1S/C41H77NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,41H,5-12,17-18,23-40H2,1-
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