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DODMA (Ionizable Cationic Lipid)

DODMA (Ionizable Cationic Lipid)

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DODMA Information

DODMA: DODMA, or 1,2-dioleyloxy-3-dimethylaminopropane, is a cationic lipid commonly used as a non-viral carrier for gene therapy. It is utilized in the preparation of cationic liposomes or lipid nanoparticles (LNP) requiring a neutral or low zeta potential. DODMA exhibits high efficacy in encapsulating nucleic acids, attributed to its capability to transiently reduce pH.

Chemical Specifications

Property Value
Hygroscopic No
Light Sensitive No
Molecular Formula C41H81NO2
Percent Composition C 79.41%, H 13.17%, N 2.26%, O 5.16%
Purity >99%
Stability 1 Year
Storage Temperature -20°C
CAS Number 104162-47-2
Formula Weight (g/mol) 620.1
Exact Mass 619.63

Physical Specifications

Property Value
Appearance Colorless to pale yellow liquid
Solubility Insoluble in water, soluble in organic solvents
Melting Point -
Boiling Point Approximately 170°C (at 5 mmHg)
Density ~0.90 g/cm³
pH Neutral
Stability Stable under normal conditions
Reactivity Non-reactive with common chemicals
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