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Anionic PS-Based

Anionic PS-Based

Regular price $350.00 USD
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Anionic PS-Based Tracer Liposomes

General Information

Anionic PS-Based Tracer Liposomes are specialized liposomal formulations that utilize the anionic lipid PS (Phosphatidylserine) for the efficient tracking and tracing of liposomes in biological systems. These liposomes are labeled with detectable tracers, such as fluorescent dyes or radioactive isotopes, allowing for detailed monitoring of their distribution, uptake, and biodistribution in both in vivo and in vitro studies.

Applications

These tracer liposomes are particularly effective in research involving cell signaling, apoptosis studies, and immune response research. The anionic nature of PS enhances interactions with specific receptors and cellular processes, making these liposomes ideal for studies requiring precise tracking in biological systems.

Benefits

Anionic PS-Based Tracer Liposomes provide real-time insights into the behavior and distribution of liposomes in biological systems, offering valuable data for the development of targeted therapies and the study of cellular processes. This technology is critical for optimizing liposomal formulations and understanding their interactions within biological environments.

Materials Needed:

  • Anionic PS-Based Tracer Liposomes (labeled with desired tracer)
  • Phosphate-buffered saline (PBS) for dilution
  • Dynamic Light Scattering (DLS) instrument for particle size analysis
  • Fluorescence or radioactivity detection equipment
  • Refrigeration storage (4°C)
  • Gloves and appropriate PPE

Procedure:

1. Preparation:

  • Ensure that the Anionic PS-Based Tracer Liposomes are stored at the recommended temperature (typically 4°C) before use.
  • Prepare the necessary dosage based on the experimental or clinical requirements.

2. Dilution:

  • Prior to administration or experimental use, dilute the liposomes in PBS to the desired concentration. Use sterile techniques to avoid contamination.

3. Administration (for research purposes):

  • Administer the diluted Tracer Liposomes to the appropriate cell culture or animal model. The dosage and method of administration will depend on the experimental design.

4. Detection and Analysis:

  • Use appropriate detection equipment (e.g., fluorescence microscopy, gamma counter) to monitor the distribution and uptake of the Anionic PS-Based Tracer Liposomes in the biological system.

5. Quality Control:

  • Assess the stability and integrity of the Tracer Liposomes using DLS and other relevant techniques to ensure accurate tracing results.

6. Storage:

  • Store any remaining Tracer Liposomes at 4°C. Avoid repeated freeze-thaw cycles to maintain stability and tracer integrity.

Specifications

Specification Details
Lipid Composition PS:DOPC:Cholesterol (20:50:30)
Liposomal Size 100-150 nm (can be customized)
Tracer Type Fluorescent dye, radioactive isotope, or other markers
Storage Temperature 4°C
Usage Single-use, research and clinical applications
Applications Biodistribution studies, cell signaling research, apoptosis studies, immune response research

Anionic PS-Based Tracer Liposomes are designed to enhance interactions with specific cellular receptors and processes, making them ideal for studies in cell signaling, apoptosis, and immune response. By incorporating detectable tracers, such as fluorescent dyes or radioactive markers, these liposomes allow researchers to monitor their distribution and uptake in real-time, providing critical data for understanding their behavior in biological environments. This information is essential for optimizing therapeutic strategies and understanding cellular mechanisms.

Apurun ensures secure shipping of Anionic PS-Based Tracer Liposomes, with temperature-controlled packaging to maintain product integrity. Standard shipping times apply, with options for expedited delivery available upon request.

Store Anionic PS-Based Tracer Liposomes at 4°C. Protect from light (if labeled with fluorescent tracers) and avoid repeated freeze-thaw cycles to maintain efficacy. Proper handling procedures should be followed to ensure safety and product quality.

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