General Information
Saturated Phosphatidylcholine (PC) Lipid Extract-Based Lyophilized Liposomes are specialized liposomal formulations that incorporate saturated PC lipid extracts. These liposomes have undergone lyophilization (freeze-drying), allowing them to be stored in a stable, dry form and reconstituted when needed. Saturated PC is known for its role in providing structural integrity to cell membranes and its high stability, making these liposomes particularly useful in drug delivery, cosmetic formulations, and nutritional supplements.
Applications
Saturated PC Lipid Extract-Based Lyophilized Liposomes are used in various industries, including pharmaceuticals, cosmetics, and nutraceuticals. Their lyophilized form ensures long-term stability, making them convenient for storage and transport. Upon reconstitution, these liposomes can be utilized in both in vitro and in vivo studies, providing a stable and effective delivery system for bioactive compounds, including drugs, vitamins, and other therapeutic agents.
Benefits
These liposomes offer the benefits of extended shelf life and stability due to lyophilization, combined with the structural integrity provided by saturated PC lipids. This makes them an excellent choice for delivering stable and effective formulations in pharmaceutical, cosmetic, and nutritional applications.
Materials Needed:
- Saturated PC Lipid Extract-Based Lyophilized Liposomes
- Sterile water or buffer solution for reconstitution
- Phosphate-buffered saline (PBS) for further dilution
- Dynamic Light Scattering (DLS) instrument for particle size analysis
- Refrigeration storage (2-8°C)
- Gloves and appropriate PPE
Procedure:
1. Reconstitution:
- Add sterile water or buffer solution to the lyophilized liposomes. The volume of liquid should be based on the desired final concentration.
- Gently swirl or vortex the vial until the liposomes are fully reconstituted. Avoid vigorous shaking to prevent foaming or damage to the liposomes.
2. Dilution:
- After reconstitution, further dilute the liposomes in PBS if necessary to achieve the desired working concentration.
3. Administration (for research purposes):
- Administer the reconstituted liposomes to the appropriate cell culture or animal model. The dosage and method of administration will depend on the experimental design.
4. Quality Control:
- Use DLS and other analytical methods to confirm the size and stability of the reconstituted liposomes. Ensure that the liposomal structure has been preserved post-lyophilization.
5. Storage:
- Store any remaining reconstituted liposomes at 2-8°C. For long-term storage, it is recommended to keep the liposomes in their lyophilized form.
Specifications
| Specification | Details |
|---|---|
| Lipid Composition | Saturated PC Lipid Extracts:Cholesterol (Varies depending on formulation) |
| Liposomal Size | 100-150 nm (can be customized) |
| Lyophilization Process | Freeze-drying with cryoprotectants to preserve structure |
| Storage Temperature | 2-8°C for reconstituted, room temperature for lyophilized form |
| Usage | Single-use, research and commercial applications |
| Applications | Drug delivery, cosmetics, nutraceuticals, therapeutic research |
Saturated Phosphatidylcholine (PC) Lipid Extract-Based Lyophilized Liposomes are designed for applications where high stability and structural integrity are critical. Saturated PC lipids provide a stable bilayer structure, making these liposomes suitable for delivering active ingredients in pharmaceutical, cosmetic, and nutritional applications. Upon reconstitution, these liposomes retain their structural integrity, offering consistent performance in delivering bioactive compounds. The lyophilization process ensures long-term stability, making them a reliable choice for formulations that require extended shelf life and robust delivery systems.
Apurun ensures secure shipping of Saturated PC Lipid Extract-Based Lyophilized Liposomes, with temperature-controlled packaging to maintain product integrity. Lyophilized liposomes can be shipped at ambient temperatures, while reconstituted liposomes should be shipped with cold packs. Standard shipping times apply, with options for expedited delivery available upon request.
Store Saturated PC Lipid Extract-Based Lyophilized Liposomes at room temperature in their lyophilized form. After reconstitution, store the liposomes at 2-8°C. Protect from light and avoid repeated freeze-thaw cycles to maintain efficacy. Proper handling procedures should be followed to ensure safety and product quality.
